Is cognitive training neuroprotective in early psychosis?

PI: Sophia Vinogradov, MD

The purpose of this study is to perform longitudinal high-resolution 7T MRI and Prisma 3T MRI in participants with first-episode psychosis (FEP) enrolled in our ongoing randomized controlled clinical trial (RCT) of cognitive training. We seek to determine whether a 12-week course of intensive cognitive training of auditory processing in young FEP patients delivered remotely as a stand-alone treatment is neuroprotective against neural tissue loss in auditory cortex (superior temporal gyrus, STG), and possibly in other cortical regions. We will also observe the effects of training on white matter integrity in the brain.

This study is funded by an NIMH grant and a private donor.

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Objective

The objective of this study is to observe changes in gray matter volume and white matter integrity in key focal regions of the brain over time, and associations with changes in behavioral, functional, and cognitive outcomes in Mini-COTES.

Population

The population being studied includes Mini-COTES participants and age and gender matched Healthy Control.

Study Design

This study is a an observational neuroimaging of 3T and 7T imaging scans at Baseline, Post-Training, 6 Month Follow Up (contemporaneous with Mini-COTES appointments).

Is cognitive training neuroprotective in early psychosis?

Objective

Population

Study Design

Current Studies

Cognitive Training Studies

Measurement-Based Care Studies

Other Studies

Is cognitive training neuroprotective in early psychosis?

+ Objective

+ Population

+ Study Design

Current Studies

+ Cognitive Training Studies

+ Measurement-Based Care Studies

+ Other Studies

Objective

Population

Study Design

Cognitive Training Studies

Measurement-Based Care Studies

Other Studies