NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration
Schizophrenia, a serious mental illness, is associated with evidence of NMDA receptor (NMDAR) dysfunction and characterized by cognitive impairments that reflect impaired value updating and feedback-driven control. However, the cellular and circuit-level mechanisms underlying these disruptions remain unclear. Here, we test how NMDA receptor (NMDAR) signaling in the medial prefrontal cortex (mPFC) contributes to adaptive decision-making by combining targeted genetic ablation in mice and systemic...