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Suicidal ideation and attempts are common in first-episode psychosis (FEP), but less is known about how these outcomes change in large, community-based, coordinated specialty care (CSC) settings. This longitudinal cohort study examined 2951 individuals with FEP enrolled in 87 CSC clinics across 15 states in the Early Psychosis Intervention Network between 2019 and 2024. Suicide-related outcomes were assessed at admission and every 6 months for up to 2 years. At admission, 34% reported suicidal...

CONCLUSIONS: Hospitalizations decreased substantially after CSC admission and remained low over 2 years in this large national FEP cohort. Prior hospitalization and markers of earlier illness course (younger age and shorter DUP) were associated with higher hospitalization burden, highlighting targets for CSC care refinement.

Schizophrenia, a serious mental illness, is associated with evidence of NMDA receptor (NMDAR) dysfunction and characterized by cognitive impairments that reflect impaired value updating and feedback-driven control. However, the cellular and circuit-level mechanisms underlying these disruptions remain unclear. Here, we test how NMDA receptor (NMDAR) signaling in the medial prefrontal cortex (mPFC) contributes to adaptive decision-making by combining targeted genetic ablation in mice and systemic...

CONCLUSIONS: A brief, self-administered, and scalable brain health battery demonstrates associations with military vocational aptitude and with neurocognitive domains associated with cognitive resilience. Future studies should evaluate whether integrating these assessments into current practices predicts success in Basic Combat Training, guides military progression, and supports long-term cognitive screening and monitoring across the Armed Forces.